Name | 4-Fluorobenzenesulfonyl chloride |
Synonyms | 4-Fluorobenzenesulfonyl 4-FLUOROBENZENSULFONYL CHLORIDE 4-fluoro-benzenesulfonylchlorid P-Fluorobenzenesulfonyl chloride 4-Fluorobenzenesulfonyl chloride P-FLUOROBENZENESULFONYL CHLORIDE 4-FLUOROBENZENESULFONYL CHLORIDE 4-FLUOROBENZENESULPHONYL CHLORIDE 4-Fluorobenzenesulphonyl chloride Benzenesulfonyl chloride, 4-fluoro- 4-FLUOROBENZENESULFONIC ACID CHLORIDE |
CAS | 349-88-2 |
EINECS | 206-493-0 |
InChI | InChI=1/C6H5F.Cl2O2S/c7-6-4-2-1-3-5-6;1-5(2,3)4/h1-5H |
InChIKey | BFXHJFKKRGVUMU-UHFFFAOYSA-N |
Molecular Formula | C6H4ClFO2S |
Molar Mass | 194.61 |
Density | 1.467 (estimate) |
Melting Point | 29-31 °C (lit.) |
Boling Point | 95-96 °C/2 mmHg (lit.) |
Flash Point | >230°F |
Solubility | Soluble in water (reacts), toluene, and dioxane |
Appearance | Bright brown crystal |
Color | White to light brown |
BRN | 2091633 |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Sensitive | Moisture Sensitive |
MDL | MFCD00007438 |
Hazard Symbols | C - Corrosive |
Risk Codes | 34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - S27 - Take off immediately all contaminated clothing. |
UN IDs | UN 3261 8/PG 2 |
WGK Germany | 3 |
TSCA | T |
HS Code | 29049090 |
Hazard Note | Corrosive |
Hazard Class | 8 |
Packing Group | II |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | 4-fluorobenzenesulfonyl chloride has a melting point of 29-31°C, a density of 1.47, a boiling point of 95-96°C/2 mmHg, and a solid appearance at normal temperature and pressure. It is a common organic synthesis intermediate, 4-fluorobenzenesulfonyl chloride can be dissolved in N,N-dimethylformamide and other strong polar organic solvents. |
Use | 4-fluorobenzenesulfonyl chloride is a common organic synthesis intermediate. The main purpose is to protect hydroxyl and amino groups. Its effect is similar to that of p-toluenesulfonyl chloride. However, due to the strong electron-absorbing ability of the fluorine atom on the benzene ring, the hydroxyl group is combined with the hydroxyl group protected by p-toluenesulfonyl chloride, and its leaving ability is stronger, it is more conducive to the subsequent nucleophilic substitution reaction. |
Preparation | 4-fluorobenzenesulfonyl chloride is obtained by one-step chlorination reaction starting from p-fluorobenzenesulfonate. |